Ga naar hoofdinhoud


TAPTOE – Tackling And Preventing The Opioid Epidemic, is a research consortium that is part of the Dutch National Research Agenda. The research focuses on the entire trajectory from prescribing opioids to long term use and their tapering.

Within the TAPTOE consortium universities, institutions and policy makers work together since 2018 in order to prevent a possible opioid problem in the Netherlands.

All publications will be linked here.


  • Bedene, A., Lijfering, W. M., Niesters, M., van Velzen, M., Rosendaal, F. R., Bouvy, M. L., Dahan, A., van Dorp, E. L. (2019). Opioid prescription patterns and risk factors associated with opioid use in the Netherlands. JAMA network open2(8), e1910223-e1910223:
  • Kalkman, G. A., Kramers, C., van Dongen, R. T., van den Brink, W., & Schellekens, A. (2019). Trends in use and misuse of opioids in the Netherlands: a retrospective, multi-source database study. The Lancet Public Health4(10), e498-e505:


  • Weesie, Y. M., Hek, K., Schermer, T. R., Schellevis, F. G., Leufkens, H. G., Rook, E. J., & van Dijk, L. (2020). Use of opioids increases with age in older adults: An observational study (2005–2017). Frontiers in Pharmacology11, 648:
  • Bedene, A., van Dorp, E. L., Faquih, T., Cannegieter, S. C., Mook-Kanamori, D. O., Niesters, M., Gademan, M.J., Rosendaal, F.R., Bouvy, M.L., Dahan, A., Lijfering, W. M. (2020). Causes and consequences of the opioid epidemic in the Netherlands: a population-based cohort study. Scientific reports10(1), 1-9:


  • Pierce, M., van Amsterdam, J., Kalkman, G. A., Schellekens, A., & van den Brink, W. (2021). Is Europe facing an opioid crisis like the United States? An analysis of opioid use and related adverse effects in 19 European countries between 2010 and 2018European Psychiatry64(1):
  • Bedene, A., Strmljan, A., van Dorp, E. L., Udovič, M., Lijfering, W. M., Niesters, M., Rosendaal, F.R., Dahan, A., Fürst, J. (2021). Comparison of Two Different Analgesic Prescription Strategies and Healthcare Systems: Slovenia vs. the NetherlandsFrontiers in Pain Research, 55:
  • (Dutch article) Veldman, S. E., Vroon, L. C., Melis, E. J., van den Heuvel, S. A. S., Schellekens, A. F. A., & Kramers, C. (2021). Opioïden afbouwen in de eerstelijnszorg [Tapering of opioid use in primary care]. Nederlands Tijdschrift voor Geneeskunde165: Ned Tijdschr Geneeskd. 2021;165:D5657
  • Schellekens, A. F., Veldman, S. E., Suranto, E. S., van Rijswijk, S. M., van der Wal, S. E., Schene, A. H., & van Beek, M. H. (2021). Beneficial effects of opioid rotation to buprenorphine/naloxone on opioid misuse, craving, mental health, and pain control in chronic non-cancer pain patients with opioid use disorder. Journal of clinical medicine10(16), 3727.:


  • Dahan, A., van Lemmen, M., Jansen, S., Simons, P., & van der Schrier, R. (2022). Buprenorphine: a treatment and cause of opioid-induced respiratory depression. British Journal of Anaesthesia128(3), 402-404:
  • van der Schrier, R., Dahan, J. D., Boon, M., Sarton, E., van Velzen, M., Niesters, M., & Dahan, A. (2022). Advances in Reversal Strategies of Opioid-induced Respiratory Toxicity. Anesthesiology136(4), 618-632:
  • Algera, M. H., Cotten, J. F., van Velzen, M., Niesters, M., Boon, M., Shoham, D. S., … & Dahan, A. (2022). Are thyrotropin‐releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid‐induced respiratory depression?Pharmacology Research & Perspectives10(3), e00974:
  • Veldman, S., van Beek, M., van Rijswijk, S., Ellerbroek, H., Timmerman, H., van der Wal, S., … & Schellekens, A. (2022). Effects of opioid rotation to buprenorphine/naloxone on pain, pain thresholds, pain tolerance, and quality of life in patients with chronic pain and opioid use disorder. Pain163(5), 955-963:
  • Algera, M. H., Cotten, J. F., van Velzen, M., Niesters, M., Boon, M., Shoham, D. S., … & Dahan, A. (2022). Respiratory effects of thyrotropin-releasing hormone and its analogue taltirelin on opioid-induced respiratory depressionBritish Journal of Anaesthesia, 129(1):e4-e6.:
  • Bedene, A., Lijfering, W.M., Sesmu Arbous, M., Rosendaal, F.R., Dahan, A., van Dorp, E.L.A. (2022). Association between prescription opioid use and unplanned intensive care unit admission and mortality in the adult population of the Netherlands: a registry study. British Journal of Anaesthesia:, 29(2):254-262.: 
  • Kalkman, G. A., van den Brink, W., Pierce, M., Atsma, F., Vissers, K. C., Schers, H. J., … & Schellekens, A. F. (2022). Monitoring Opioids in Europe: The Need for Shared Definitions and Measuring Drivers of Opioid Use and Related Harms. European Addiction Research 28(3), 231-240.:
  • Bedene, A., Dahan, A., Rosendaal, F.R., van Dorp, E.L.A. (2022). Opioid epidemic: lessons learned and updated recommendations for misuse involving prescription versus non-prescription opioids. Expert Review Of Clinicial Pharmacology, 1-14.:
Back To Top